The SARS Coronavirus E Protein Interacts with PALS1 and Alters Tight Junction Formation and Epithelial Morphogenesis

@inproceedings{Teoh2010TheSC,
  title={The SARS Coronavirus E Protein Interacts with PALS1 and Alters Tight Junction Formation and Epithelial Morphogenesis},
  author={K. Teoh and Y L Siu and Wing-Lim Chan and Marc Alexander Schl{\"u}ter and Chia-Jen Liu and Joseph Sriyal Malik Peiris and Roberto Bruzzone and Benjamin L. Margolis and B{\'e}atrice Nal},
  booktitle={Molecular biology of the cell},
  year={2010}
}
Intercellular tight junctions define epithelial apicobasal polarity and form a physical fence which protects underlying tissues from pathogen invasions. PALS1, a tight junction-associated protein, is a member of the CRUMBS3-PALS1-PATJ polarity complex, which is crucial for the establishment and maintenance of epithelial polarity in mammals. Here we report that the carboxy-terminal domain of the SARS-CoV E small envelope protein (E) binds to human PALS1. Using coimmunoprecipitation and pull-down… CONTINUE READING
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