The SANT domain: a unique histone-tail-binding module?

  title={The SANT domain: a unique histone-tail-binding module?},
  author={Laurie A. Boyer and Robert R. Latek and Craig L. Peterson},
  journal={Nature Reviews Molecular Cell Biology},
Chromatin-remodelling complexes have an important role in all DNA-mediated processes and, although much is known about how these enzymes regulate chromosomal DNA accessibility, how they interact with their histone substrates has remained unclear. However, recent studies have indicated that the SANT domain has a central role in chromatin remodelling by functioning as a unique histone-interaction module that couples histone binding to enzyme catalysis. 

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