The SAND domain structure defines a novel DNA-binding fold in transcriptional regulation


The SAND domain is a conserved sequence motif found in a number of nuclear proteins, including the Sp100 family and NUDR. These are thought to play important roles in chromatin-dependent transcriptional regulation and are linked to many diseases. We have determined the three-dimensional (3D) structure of the SAND domain from Sp100b. The structure represents… (More)
DOI: 10.1038/89675

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