The SAM domain of polyhomeotic forms a helical polymer

@article{Kim2002TheSD,
  title={The SAM domain of polyhomeotic forms a helical polymer},
  author={Chongwoo A. Kim and Mari Gingery and Rosemarie M. Pilpa and James U. Bowie},
  journal={Nature Structural Biology},
  year={2002},
  volume={9},
  pages={453-457}
}
The polycomb group (PcG) proteins are important in the maintenance of stable repression patterns during development. Several PcG members contain a protein–protein interaction module called a SAM domain (also known as SPM, PNT and HLH). Here we report the high-resolution structure of the SAM domain of polyhomeotic (Ph). Ph-SAM forms a helical polymer structure, providing a likely mechanism for the extension of PcG complexes. The structure of the polymer resembles that formed by the SAM domain of… CONTINUE READING

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