The S40 residue in HIV-1 Gag p6 impacts local and distal budding determinants, revealing additional late domain activities

@inproceedings{Watanabe2013TheSR,
  title={The S40 residue in HIV-1 Gag p6 impacts local and distal budding determinants, revealing additional late domain activities},
  author={Susan M. Watanabe and M H Chen and M Badaruzzaman Khan and Lorna S. Ehrlich and Kimdar Sherefa Kemal and Barbara Weiser and Binshan Shi and Chaoping Chen and Michael D. Powell and Kathryn M Anastos and Harold Christopher Burger and Carol A Carter},
  booktitle={Retrovirology},
  year={2013}
}
HIV-1 budding is directed primarily by two motifs in Gag p6 designated as late domain-1 and −2 that recruit ESCRT machinery by binding Tsg101 and Alix, respectively, and by poorly characterized determinants in the capsid (CA) domain. Here, we report that a conserved Gag p6 residue, S40, impacts budding mediated by all of these determinants. Whereas budding normally results in formation of single spherical particles ~100 nm in diameter and containing a characteristic electron-dense conical core… CONTINUE READING
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