The S4-S5 linker directly couples voltage sensor movement to the activation gate in the human ether-a'-go-go-related gene (hERG) K+ channel.

@article{Ferrer2006TheSL,
  title={The S4-S5 linker directly couples voltage sensor movement to the activation gate in the human ether-a'-go-go-related gene (hERG) K+ channel.},
  author={Tania Ferrer and Jason D Rupp and David R Piper and Martin Tristani-Firouzi},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 18},
  pages={12858-64}
}
A key unresolved question regarding the basic function of voltage-gated ion channels is how movement of the voltage sensor is coupled to channel opening. We previously proposed that the S4-S5 linker couples voltage sensor movement to the S6 domain in the human ether-a'-go-go-related gene (hERG) K+ channel. The recently solved crystal structure of the voltage-gated Kv1.2 channel reveals that the S4-S5 linker is the structural link between the voltage sensing and pore domains. In this study, we… CONTINUE READING
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