The S100 family of EF-hand calcium-binding proteins: functions and pathology.

@article{Schfer1996TheSF,
  title={The S100 family of EF-hand calcium-binding proteins: functions and pathology.},
  author={Beat W. Sch{\"a}fer and Claus Wilhelm Heizmann},
  journal={Trends in biochemical sciences},
  year={1996},
  volume={21 4},
  pages={134-40}
}
Calcium lons as second messengers control many biological processes, at least in part, via interaction with a large number of Ca(2+)-binding proteins. One class of these proteins shares a common Ca(2+)-binding motif, the EF-hand, Here, we describe some functional aspects of EF-hand proteins, which have been found recently in different cellular compartments. Novel links between EF-hand proteins, particularly S100 proteins, and specific diseases are now emerging. 
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