The S. pombe mitotic regulator Cut12 promotes spindle pole body activation and integration into the nuclear envelope

@inproceedings{Tallada2009TheSP,
  title={The S. pombe mitotic regulator Cut12 promotes spindle pole body activation and integration into the nuclear envelope},
  author={Victor A. Tallada and Kenji Tanaka and Mitsuhiro Yanagida and Iain M Hagan},
  booktitle={The Journal of cell biology},
  year={2009}
}
The fission yeast spindle pole body (SPB) comprises a cytoplasmic structure that is separated from an ill-defined nuclear component by the nuclear envelope. Upon mitotic commitment, the nuclear envelope separating these domains disperses as the two SPBs integrate into a hole that forms in the nuclear envelope. The SPB component Cut12 is linked to cell cycle control, as dominant cut12.s11 mutations suppress the mitotic commitment defect of cdc25.22 cells and elevated Cdc25 levels suppress the… CONTINUE READING
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