The Runx genes: lineage-specific oncogenes and tumor suppressors

@article{Cameron2004TheRG,
  title={The Runx genes: lineage-specific oncogenes and tumor suppressors},
  author={Ewan R Cameron and James C Neil},
  journal={Oncogene},
  year={2004},
  volume={23},
  pages={4308-4314}
}
The Runx genes present a challenge to the simple binary classification of cancer genes as oncogenes or tumor suppressors. There is evidence that loss of function of two of the three mammalian Runx genes promotes cancer, but in a highly lineage-restricted manner. In human leukemias, the RUNX1 gene is involved in various chromosomal translocation events that create oncogenic fusion proteins, at least some of which appear to function as dominant-negative inhibitors of the normal gene product… CONTINUE READING
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References

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Showing 1-10 of 13 references

Cancer

  • Y Alvarez, MD Coll, P Bastida, JJ Ortega, MR. Caballin
  • Genet. Cytogenet., 140, 58–61.
  • 2003
Highly Influential
4 Excerpts

Blood Cells Mol

  • ER Cameron, K Blyth, +7 authors JC. Neil
  • Dis., 30, 194–200.
  • 2003
1 Excerpt

Cell Biol

  • Coffman JA.
  • Int., 27, 315–324.
  • 2003

Mech

  • A Robertson, C Dickey, J McCarthy, J. Coffman
  • Dev., 117, 327–330.
  • 2002
1 Excerpt

Cancer Genet

  • B Streubel, P Valent, K Lechner, C. Fonatsch
  • Cytogenet., 124, 42–46.
  • 2001

Br

  • B. Lange
  • J. Haematol., 110, 512–524.
  • 2000

Mol

  • A Pozner, D Goldenberg, +4 authors Y. Groner
  • Cell. Biol., 20, 2297–2307.
  • 2000

Semin

  • JC Wheeler, K Shigesada, JP Gergen, Y. Ito
  • Cell Dev. Biol., 11, 369–375.
  • 2000

Nat

  • DA Yergeau, CJ Hetherington, +7 authors DE. Zhang
  • Genet., 15, 303–306.
  • 1997

DNA Cell

  • D Levanon, Y Bernstein, +6 authors Y. Groner
  • Biol., 15, 175–185.
  • 1996
1 Excerpt

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