The Roles of the Methyl-CpG Binding Proteins in Cancer.

  title={The Roles of the Methyl-CpG Binding Proteins in Cancer.},
  author={Lee Parry and Alan R. Clarke},
  journal={Genes & cancer},
  volume={2 6},
The methyl-CpG binding proteins (MBPs) interpret the methylation of DNA and its components. The number of MBPs in the human body currently stands at 15, which are split into 3 branches, a reflection of the intricate mechanisms of gene regulation. Each branch utilizes a different mechanism for interacting with methylated DNA or its components. These interactions function to direct gene expression and maintain or alter DNA architecture. It is these functions that are commonly exploited in human… CONTINUE READING
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