The Roles of Placental Growth Hormone and Placental Lactogen in the Regulation of Human Fetal Growth and Development

@article{Handwerger2000TheRO,
  title={The Roles of Placental Growth Hormone and Placental Lactogen in the Regulation of Human Fetal Growth and Development},
  author={Stuart Handwerger and Michael Freemark},
  journal={Journal of Pediatric Endocrinology and Metabolism},
  year={2000},
  volume={13},
  pages={343 - 356}
}
The human growth hormone (hGH)/human placental lactogen (hPL) gene family, which consists of two GH and three PL genes, is important in the regulation of maternal and fetal metabolism and the growth and development of the fetus. During pregnancy, pituitary GH (hGH-N) expression in the mother is suppressed; and hGH-V, a GH variant expressed by the placenta, becomes the predominant GH in the mother. hPL, which is the product of the hPL-A and hPL-B genes, is secreted into both the maternal and… 

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