The Roles of N- and C-terminal determinants in the activation of the Kv2.1 potassium channel.

@article{Ju2003TheRO,
  title={The Roles of N- and C-terminal determinants in the activation of the Kv2.1 potassium channel.},
  author={Min Ju and Louisa Stevens and Emma Leadbitter and Dennis Wray},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 15},
  pages={12769-78}
}
The human and rat forms of the Kv2.1 channel have identical amino acids over the membrane-spanning regions and differ only in the N- and C-terminal intracellular regions. Rat Kv2.1 activates much faster than human Kv2.1. Here we have studied the role of the N- and C-terminal residues that determine this difference in activation kinetics between the two channels. For this, we constructed mutants and chimeras between the two channels, expressed them in oocytes, and recorded currents by two… CONTINUE READING

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IUPHAR Compendium of Voltage-gated Ion Channels, pp. 86–87, IUPHAR Media, Leeds, UK N- and C-terminal Domains of Kv2.1 12778 by gest on Jne 30

  • W. A. Catterall, K. G. Chandy, G. A. Gutman
  • January 29,
  • 2002
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