The Roles of Lysosomes in Inflammation and Autoimmune Diseases.

  title={The Roles of Lysosomes in Inflammation and Autoimmune Diseases.},
  author={Wei Ge and Dongxu Li and Yanpan Gao and Xuetao Cao},
  journal={International reviews of immunology},
  volume={34 5},
Lysosomes perform a range of functions, some of which, such as degradation, are common to all cell types. Others, such as secretion or lysosomal exocytosis, are more specialised and tend to involve fusion of this organelle with the cell surface to release its contents. This review describes lysosomal regulation of the inflammatory glucocorticoid signaling pathways, and summarizes the roles of lysosomes in negatively or positively modulating the production of inflammatory cytokines. We also… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.


Publications referenced by this paper.
Showing 1-10 of 98 references

Hypoxia enhances lysosomal TNF-alpha degradation in mouse peritoneal macrophages.

American journal of physiology. Cell physiology • 2008
View 4 Excerpts
Highly Influenced

Toll-like receptors in systemic autoimmune disease

Nature Reviews Immunology • 2006
View 7 Excerpts
Highly Influenced

Roles of Pro- and Anti-Inflammatory Cytokines in the Pathogenesis of SLE

Journal of biomedicine & biotechnology • 2012
View 10 Excerpts
Highly Influenced

Clearance of apoptotic cells in human SLE.

Current directions in autoimmunity • 2006
View 10 Excerpts
Highly Influenced

An inhibitor of cathepsin K, icariin suppresses cartilage and bone degradation in mice of collagen-induced arthritis.

Phytomedicine : international journal of phytotherapy and phytopharmacology • 2013
View 1 Excerpt

Similar Papers

Loading similar papers…