The Roles of IL-1, IL-6, and TNFα in the Feeding Responses to Endotoxin and Influenza Virus Infection in Mice

@article{Swiergiel1999TheRO,
  title={The Roles of IL-1, IL-6, and TNFα in the Feeding Responses to Endotoxin and Influenza Virus Infection in Mice},
  author={Arthur H. Swiergiel and Adrian J. Dunn},
  journal={Brain, Behavior, and Immunity},
  year={1999},
  volume={13},
  pages={252-265}
}
Influenza infection or administration of bacterial endotoxin (lipopolysaccharide, LPS) results in diminished feeding and loss of body weight. It has been suggested that these effects may be mediated by cytokines, such as interleukin-1 (IL-1), interleukin-6 (IL-6), and/or tumor necrosis factor-alpha (TNFalpha). To assess the potential role of these cytokines, we tested the ability of the naturally occurring IL-1-receptor antagonist (IL-1ra), a monoclonal antibody to mouse IL-6 (IL-6mAb), and a… CONTINUE READING

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