Dopamine has been implicated in the modulation of working memory via its interactions with circuits located in the prefrontal cortex of rodents and non-human primates. However, the role that pathways triggered by dopamine receptor subtypes play in affecting processes of working memory remains unclear. In humans, the evidence for dopaminergic modulation of working memory is controversial and the neurological substrates for dopamine’s modulatory effects are not fully understood. This paper will… CONTINUE READING
Figure 1: Subdivisions of the prefrontal cortex (PFC).The PFC is composed of all regions anterior to the frontal eye fields, namely the ventromedial, ventrolateral and dorsolateral frontal regions and the frontal poles. Reproduced with permission from Fellows (2004).