The Role of the Transcription Factor CREB in Immune Function

@article{Wen2010TheRO,
  title={The Role of the Transcription Factor CREB in Immune Function},
  author={An Wen and Kathleen M Sakamoto and Lloyd S. Miller},
  journal={The Journal of Immunology},
  year={2010},
  volume={185},
  pages={6413 - 6419}
}
CREB is a transcription factor that regulates diverse cellular responses, including proliferation, survival, and differentiation. CREB is induced by a variety of growth factors and inflammatory signals and subsequently mediates the transcription of genes containing a cAMP-responsive element. Several immune-related genes possess this cAMP-responsive element, including IL-2, IL-6, IL-10, and TNF-α. In addition, phosphorylated CREB has been proposed to directly inhibit NF-κB activation by blocking… Expand
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