The Role of the Striatum in Compulsive Behavior in Intact and Orbitofrontal-Cortex-Lesioned Rats: Possible Involvement of the Serotonergic System

@article{Schilman2010TheRO,
  title={The Role of the Striatum in Compulsive Behavior in Intact and Orbitofrontal-Cortex-Lesioned Rats: Possible Involvement of the Serotonergic System},
  author={Eduardo A Schilman and Oded Klavir and Christine Winter and Reinhard Sohr and Daphna Joel},
  journal={Neuropsychopharmacology},
  year={2010},
  volume={35},
  pages={1026-1039}
}
In the signal attenuation rat model of obsessive-compulsive disorder (OCD), ‘compulsive’ behavior is induced by attenuating a signal indicating that a lever-press response was effective in producing food. We have recently found that lesions to the rat orbitofrontal cortex (OFC) led to an increase in compulsive lever-pressing that was prevented by systemic administration of the selective serotonin reuptake inhibitor paroxetine, and paralleled by an increase in the density of the striatal… CONTINUE READING
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