The Role of the Putative Inactivation Lid in Sodium Channel Gating Current Immobilization

@article{Sheets2000TheRO,
  title={The Role of the Putative Inactivation Lid in Sodium Channel Gating Current Immobilization},
  author={Michael F. Sheets and John W. Kyle and Dorothy A. Hanck},
  journal={The Journal of General Physiology},
  year={2000},
  volume={115},
  pages={609 - 620}
}
We investigated the contribution of the putative inactivation lid in voltage-gated sodium channels to gating charge immobilization (i.e., the slow return of gating charge during repolarization) by studying a lid-modified mutant of the human heart sodium channel (hH1a) that had the phenylalanine at position 1485 in the isoleucine, phenylalanine, and methionine (IFM) region of the domain III-IV linker mutated to a cysteine (ICM-hH1a). Residual fast inactivation of ICM-hH1a in fused tsA201 cells… CONTINUE READING

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