The Role of the Perirhinal Cortex and Hippocampus in Learning, Memory, and Perception

@article{Buckley2005TheRO,
  title={The Role of the Perirhinal Cortex and Hippocampus in Learning, Memory, and Perception},
  author={Mark J Buckley},
  journal={Quarterly Journal of Experimental Psychology},
  year={2005},
  volume={58},
  pages={246 - 268}
}
  • M. Buckley
  • Published 1 July 2005
  • Biology, Psychology
  • Quarterly Journal of Experimental Psychology
One traditional and long-held view of medial temporal lobe (MTL) function is that it contains a system of structures that are exclusively involved in memory, and that the extent of memory loss following MTL damage is simply related to the amount of MTL damage sustained. Indeed, human patients with extensive MTL damage are typically profoundly amnesic whereas patients with less extensive brain lesions centred upon the hippocampus typically exhibit only moderately severe anterograde amnesia… 
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The Roles of Perirhinal Cortex, Postrhinal Cortex, and the Fornix in Memory for Objects, Contexts, and Events in the Rat
  • M. Eacott, E. Gaffan
  • Biology, Psychology
    The Quarterly journal of experimental psychology. B, Comparative and physiological psychology
  • 2005
TLDR
Evidence is provided that despite the strong connectivity between these cortical regions and the hippocampus, the hippocampus has a distinct function of its own—combining information about objects, positions, and contexts.
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The Contribution of the Human Medial Temporal Lobe to Perception: Bridging the Gap between Animal and Human Studies
TLDR
The current article reviews the human neuropsychological literature to determine whether there is any evidence to suggest that the medial temporal lobe may be critical to higher order perceptual processes, with the hippocampus and perirhinal cortex being involved in scene and object perception, respectively.
Going beyond LTM in the MTL: A synthesis of neuropsychological and neuroimaging findings on the role of the medial temporal lobe in memory and perception
The Perceptual-Mnemonic/Feature Conjunction Model of Perirhinal Cortex Function
  • T. Bussey, L. Saksida, E. Murray
  • Biology, Psychology
    The Quarterly journal of experimental psychology. B, Comparative and physiological psychology
  • 2005
TLDR
A new view of perirhinal cortex function is proposed, one that does not assume strict modularity of function in the occipito-temporal visual stream, but replaces this idea with the notion of a hierarchical representational continuum.
Findings from animals concerning when interactions between perirhinal cortex, hippocampus and medial prefrontal cortex are necessary for recognition memory
Recognition memory: Material, processes, and substrates
TLDR
Overall, it is concluded that most, though not all, of the recent findings are in support of the proposal that a system centering on the perirhinal cortex is responsible for familiarity discrimination, particularly for single items, although there remain examples of the independent operation of the hippocampal and perIRhinal systems.
Episodic memory in aspects of large-scale brain networks
TLDR
This review focuses on the functional organization of the MTL and other neocortical areas in episodic memory and shows that brain stimulation may impact memory through modulating functional networks, carrying future implications of a novel interventional therapy for memory impairment.
Recognition memory for faces and scenes in amnesia: Dissociable roles of medial temporal lobe structures
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References

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The Roles of Perirhinal Cortex, Postrhinal Cortex, and the Fornix in Memory for Objects, Contexts, and Events in the Rat
  • M. Eacott, E. Gaffan
  • Biology, Psychology
    The Quarterly journal of experimental psychology. B, Comparative and physiological psychology
  • 2005
TLDR
Evidence is provided that despite the strong connectivity between these cortical regions and the hippocampus, the hippocampus has a distinct function of its own—combining information about objects, positions, and contexts.
Selective hippocampal lesions yield nonspatial memory impairments in rhesus monkeys
TLDR
The effects of excitotoxic lesions of one of the MTL structures, the hippocampus, on the rate of learning of discrimination problems embedded within unique contexts strongly support the idea that the difference in the effect on object memory of MTL damage in human and nonhuman primates is due to a difference to the opportunity to employ contextual cues rather than to a change in the organization of memory.
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TLDR
It is suggested that, whereas damage to the hippocampal region produces measurable memory impairment, a substantial part of the severe memory impairment produced by large medial temporal lobe lesions in humans and monkeys can be attributed to damage to entorhinal, perirHinal, and parahippocampal cortices adjacent to the hippocampusal region.
The Contribution of the Human Medial Temporal Lobe to Perception: Bridging the Gap between Animal and Human Studies
TLDR
The current article reviews the human neuropsychological literature to determine whether there is any evidence to suggest that the medial temporal lobe may be critical to higher order perceptual processes, with the hippocampus and perirhinal cortex being involved in scene and object perception, respectively.
Memory in monkeys severely impaired by combined but not by separate removal of amygdala and hippocampus
TLDR
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TLDR
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Compared to normal animals, monkeys with bilateral lesions of the perirhinal and parahippocampal cortices (PRPH lesion) were impaired on both a visual and a tactual version of the delayed nonmatching…
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