The Role of the Neurobiologist in Redefining the Diagnosis of Autism

@article{London2007TheRO,
  title={The Role of the Neurobiologist in Redefining the Diagnosis of Autism},
  author={Eric Bart London},
  journal={Brain Pathology},
  year={2007},
  volume={17}
}
  • E. London
  • Published 1 October 2007
  • Psychology, Medicine
  • Brain Pathology
Until recently, autism, along with the other developmental disabilities, was largely ignored by the medical and research community. At this early point in our understanding of the syndrome, neurobiologists and especially those who work with human brain tissue have a great deal to offer. A thorough understanding of the clinically defined syndrome is essential. Along with the other psychiatric diseases listed in the Diagnostic and Statistical Manual of Mental Disorders (DSM), autism is defined by… 
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References

SHOWING 1-10 OF 36 REFERENCES
Features of Autism in Rett Syndrome and Severe Mental Retardation
TLDR
Controlling for developmental level and motor ability, girls with RS scored more highly than those with SMR on the Sensory and Relating subscales, and there were no group differences on the Body and Object use, Language and Social and Self-help subscales.
Autism in Angelman syndrome: implications for autism research
TLDR
The study highlights the phenotypic overlap between autism and AS and increases the probability that dysregulation of UBE3A may play a role in the causation of autism.
1 WHERE WE ARE : OVERVIEW AND DEFINITIONS
HISTORICAL BACKGROUND The term “autism”, which was coined by Bleuler to characterize the negative symptoms and social alienation of individuals suffering from schizophrenia, was borrowed by both
Heritable and nonheritable risk factors for autism spectrum disorders.
TLDR
Findings of substantive differences in monozygotic-dizygotic twin concordance in the original and subsequent twin studies, coupled with higher estimates of sibling recurrence from studies conducted in the 1980s, indicated strongly that liability to ASD was heritable.
Diagnosis and Epidemiology of Autism Spectrum Disorders
  • L. Tidmarsh, F. Volkmar
  • Psychology, Medicine
    Canadian journal of psychiatry. Revue canadienne de psychiatrie
  • 2003
TLDR
An overview of the diagnostic categories of autism and other pervasive developmental disorders (PDDs) is given and the changes in the DSM classification system over the past 20 years are discussed.
Brief Report: Autism in Individuals with Down Syndrome
TLDR
Five individuals with Down syndrome may be considered to show an autism spectrum disorder after being administered the Autism Diagnostic Interview-Revised and the A-PL-ADOS, which are well-validated interview and observational diagnostic measures.
Genetic heterogeneity between the three components of the autism spectrum: a twin study.
TLDR
The results suggest the triad of impairments that define autism spectrum disorders is heterogeneous genetically, and molecular genetic research examining the three aspects separately may identify different causal pathways for the three components.
Autistic traits in the general population: a twin study.
TLDR
The data indicate that the social deficits characteristic of autism spectrum disorders are common, and it may be arbitrary where cutoffs are made between research designations of being "affected" vs "unaffected" with a pervasive developmental disorder.
Considerations for a multiaxis nomenclature system for medical genetics
TLDR
It is proposed that both phenotypic and etiologic factors should be used to generate a unified diagnostic labeling system, and the underlying assumptions of this approach are outlined.
Genetics of austim: complex aetiology for a heterogeneous disorder
TLDR
The identification of chromosomal abnormalities and Mendelian syndromes among individuals with autism, in conjunction with data from genome screens and candidate-gene studies, has helped to refine the view of the complex genetics that underlies autism spectrum conditions.
...
...