The Role of the NLRP3 Inflammasome in Fibrosis

  title={The Role of the NLRP3 Inflammasome in Fibrosis},
  author={Carol M. Artlett},
  booktitle={The open rheumatology journal},
Fibrosis leads to the deposition of collagens in organs and tissues. The resulting pathology induces a loss of function in the organ it is manifested in and this loss of function modulates the morbidity and mortality in that individual. Indeed, approximately 45% of all deaths in the Western world can be attributed to fibrosis and there are no FDA approved drugs for the treatment of fibrosis. The recent discovery of the inflammasome has led to a plethora of studies investigating this… CONTINUE READING