The Role of the Medial Frontal Cortex in Cognitive Control

@article{Ridderinkhof2004TheRO,
  title={The Role of the Medial Frontal Cortex in Cognitive Control},
  author={K. Richard Ridderinkhof and Markus Ullsperger and Eveline A. Crone and Sander Nieuwenhuis},
  journal={Science},
  year={2004},
  volume={306},
  pages={443 - 447}
}
Adaptive goal-directed behavior involves monitoring of ongoing actions and performance outcomes, and subsequent adjustments of behavior and learning. We evaluate new findings in cognitive neuroscience concerning cortical interactions that subserve the recruitment and implementation of such cognitive control. A review of primate and human studies, along with a meta-analysis of the human functional neuroimaging literature, suggest that the detection of unfavorable outcomes, response errors… 
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References

SHOWING 1-10 OF 75 REFERENCES
Dissociable Executive Functions in the Dynamic Control of Behavior: Inhibition, Error Detection, and Correction
TLDR
The present study employed event-related fMRI and EEG data to investigate the biological basis of the cognitive control of behavior and highlighted how higher cognitive functions responsible for behavioral control can result from the dynamic interplay of distinct cortical systems.
An integrative theory of prefrontal cortex function.
TLDR
It is proposed that cognitive control stems from the active maintenance of patterns of activity in the prefrontal cortex that represent goals and the means to achieve them, which provide bias signals to other brain structures whose net effect is to guide the flow of activity along neural pathways that establish the proper mappings between inputs, internal states, and outputs needed to perform a given task.
Inhibition and the right inferior frontal cortex
Performance Monitoring by the Anterior Cingulate Cortex During Saccade Countermanding
TLDR
A saccade-countermanding task affords an experimental dissociation of neural signals of error, reinforcement, and conflict, consistent with the hypothesis that the anterior cingulate cortex monitors the consequences of actions.
Selection, Integration, and Conflict Monitoring Assessing the Nature and Generality of Prefrontal Cognitive Control Mechanisms
The role of the medial prefrontal cortex in achieving goals
Dorsal anterior cingulate cortex: A role in reward-based decision making
  • G. Bush, B. Vogt, B. Rosen
  • Psychology, Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2001
TLDR
The data support a role for dACC in reward-based decision making, and by linking the human and monkey literatures, provide initial support for the existence of heterogeneity within dACC.
Anterior Cingulate Conflict Monitoring and Adjustments in Control
TLDR
Using the Stroop color-naming task and controlling for repetition effects, it is demonstrated that ACC conflict-related activity predicts both greater prefrontal cortex activity and adjustments in behavior, supporting a role of ACC conflict monitoring in the engagement of cognitive control.
Prefrontal–cingulate interactions in action monitoring
TLDR
The lateral prefrontal cortex seemed to interact with the anterior cingulate cortex in monitoring behavior and in guiding compensatory systems, and it was found that medial frontal cortex activity associated with action monitoring depended on activity in the lateral cortex.
Primate anterior cingulate cortex: Where motor control, drive and cognition interface
  • T. Paus
  • Biology, Psychology
    Nature Reviews Neuroscience
  • 2001
TLDR
It is argued that the overlap of these three domains is key to distinguishing the anterior cingulate cortex from other frontal regions, placing it in a unique position to translate intentions to actions.
...
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