The Role of the Intestinal Lymphatics in the Absorption of Two Highly Lipophilic Cholesterol Ester Transfer Protein Inhibitors (CP524,515 and CP532,623)

@article{Trevaskis2010TheRO,
  title={The Role of the Intestinal Lymphatics in the Absorption of Two Highly Lipophilic Cholesterol Ester Transfer Protein Inhibitors (CP524,515 and CP532,623)},
  author={Natalie L Trevaskis and Claire L. McEvoy and M. Mcintosh and G. Edwards and R. Shanker and W. Charman and C. J. Porter},
  journal={Pharmaceutical Research},
  year={2010},
  volume={27},
  pages={878-893}
}
ABSTRACTPurposeTo evaluate the potential role of intestinal lymphatic transport in the absorption and oral bioavailability of members of an emerging class of anti-atherosclerosis drugs (CETP inhibitors). CP524,515 and CP532,623 are structurally related with eLogD7.4 >5; however, only CP524,515 (and not CP532,623) had sufficient solubility (>50 mg/g) in long-chain triglyceride (LCT) to be considered likely to be lymphatically transported.MethodsCP524,515 and CP532,623 were administered… Expand
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