The Role of the Immune System in Huntington's Disease

@inproceedings{Ellrichmann2013TheRO,
  title={The Role of the Immune System in Huntington's Disease},
  author={Gisa Ellrichmann and Christiane Reick and Carsten Saft and Ralf Andreas Linker},
  booktitle={Clinical & developmental immunology},
  year={2013}
}
Huntington's disease (HD) is characterized by a progressive course of disease until death 15-20 years after the first symptoms occur and is caused by a mutation with expanded CAG repeats in the huntingtin (htt) protein. Mutant htt (mhtt) in the striatum is assumed to be the main reason for neurodegeneration. Knowledge about pathophysiology has rapidly improved discussing influences of excitotoxicity, mitochondrial damage, free radicals, and inflammatory mechanisms. Both innate and adaptive… CONTINUE READING
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