The Role of the Hippocampal Mineralocorticoid and Glucocorticoid Receptors in the Hypothalamo-Pituitary-Adrenal Axis of the Aged Fisher Rat

@article{Morano1994TheRO,
  title={The Role of the Hippocampal Mineralocorticoid and Glucocorticoid Receptors in the Hypothalamo-Pituitary-Adrenal Axis of the Aged Fisher Rat},
  author={Marı́a In{\'e}s Morano and Delia Vazquez and Huda Akil},
  journal={Molecular and Cellular Neuroscience},
  year={1994},
  volume={5},
  pages={400-412}
}
The aging process has been frequently associated with hippocampal neurodegeneration, loss of corticosteroid receptors, and, at the same time, dysfunction of the hypothalamo-pituitary-adrenal (HPA) axis. We were interested in characterizing simultaneously the activity of the HPA axis and status of both corticosteroid receptors (mineralocorticoid or MR and glucocorticoid or GR) in the hippocampus of aged male Fisher-344 rats. We compared intact, adrenalectomized (ADX), and corticosterone-replaced… CONTINUE READING
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