The Role of the HPA Axis in Psychiatric Disorders and CRF Antagonists as Potential Treatments
@article{Keller2006TheRO, title={The Role of the HPA Axis in Psychiatric Disorders and CRF Antagonists as Potential Treatments}, author={P. Keller and A. McCluskey and J. Morgan and S. O'Connor}, journal={Archiv der Pharmazie}, year={2006}, volume={339} }
An overview of the links between the Hypothalamic‐Pituitary‐Adrenal (HPA) axis and psychiatric disorders is presented. The current treatments are outlined, indicating that they are insufficient to meet the needs of those that suffer from these affective disorders. Therefore, there is an urgent need for the generation of new therapeutics, in particular, against new targets. The association of the corticotrophin releasing factor (CRF) and the HPA axis indicates that CRF antagonists should be… CONTINUE READING
Topics from this paper
28 Citations
Validation of Brain Angiotensin System Blockade as a Novel Drug Target in Pharmacological Treatment of Neuropsychiatric Disorders.
- Medicine
- Pharmacopsychiatry
- 2017
- 4
The Hypothalamic‐Pituitary‐Adrenal Axis in Borderline Personality Disorder: A Review
- Psychology, Medicine
- Harvard review of psychiatry
- 2009
- 52
Corticotropin-releasing factor peptide antagonists: Design, characterization and potential clinical relevance
- Biology, Medicine
- Frontiers in Neuroendocrinology
- 2014
- 23
Glutamatergic and HPA-axis pathway genes in bipolar disorder comorbid with alcohol- and substance use disorders
- Medicine
- Metabolic Brain Disease
- 2015
- 4
The center of the emotional universe: Alcohol, stress, and CRF1 amygdala circuitry.
- Psychology, Medicine
- Alcohol
- 2018
- 19
Prenatal Stress Induces Schizophrenia-Like Alterations of Serotonin 2A and Metabotropic Glutamate 2 Receptors in the Adult Offspring: Role of Maternal Immune System
- Psychology, Medicine
- The Journal of Neuroscience
- 2013
- 97
- PDF
GR gene BclI polymorphysm changes the path, but not the level, of dexamethasone-induced cortisol suppression.
- Medicine
- Journal of affective disorders
- 2014
- 5
Predominant expression of tryptophan hydroxylase 1 mRNA in the pituitary: A postmortem study in human brain
- Biology, Medicine
- Neuroscience
- 2009
- 35
References
SHOWING 1-10 OF 112 REFERENCES
The role of corticotropin-releasing factor in depression and anxiety disorders.
- Medicine
- The Journal of endocrinology
- 1999
- 1,262
- PDF
The rationale for corticotropin-releasing hormone receptor (CRH-R) antagonists to treat depression and anxiety.
- Psychology, Medicine
- Journal of psychiatric research
- 1999
- 600
The role of Corticotropin Releasing Factor in Depressive Illness: a Critical Review
- Medicine, Psychology
- Neuroscience & Biobehavioral Reviews
- 1998
- 120
The role of corticotropin-releasing factor in drug addiction.
- Medicine
- Pharmacological reviews
- 2001
- 425
- PDF
Nonpeptide Corticotropin-Releasing Hormone Receptor Type 1 Antagonists and Their Applications in Psychosomatic Disorders
- Medicine
- Neuroendocrinology
- 2004
- 19
Physiological and Neurochemical Aspects of Corticotropin-Releasing Factor Actions in the Brain: The Role of the Locus Coeruleus
- Psychology, Medicine
- Neurochemical Research
- 2004
- 52
Elevated concentrations of CSF corticotropin-releasing factor-like immunoreactivity in depressed patients.
- Medicine
- Science
- 1984
- 1,427
The Corticotropin-Releasing Factor1 Receptor Antagonist R121919 Attenuates the Behavioral and Endocrine Responses to Stress
- Medicine
- Journal of Pharmacology and Experimental Therapeutics
- 2003
- 90
- PDF