The Role of the HPA Axis in Psychiatric Disorders and CRF Antagonists as Potential Treatments

@article{Keller2006TheRO,
  title={The Role of the HPA Axis in Psychiatric Disorders and CRF Antagonists as Potential Treatments},
  author={P. Keller and A. McCluskey and J. Morgan and S. O'Connor},
  journal={Archiv der Pharmazie},
  year={2006},
  volume={339}
}
  • P. Keller, A. McCluskey, +1 author S. O'Connor
  • Published 2006
  • Medicine
  • Archiv der Pharmazie
    • An overview of the links between the Hypothalamic‐Pituitary‐Adrenal (HPA) axis and psychiatric disorders is presented. The current treatments are outlined, indicating that they are insufficient to meet the needs of those that suffer from these affective disorders. Therefore, there is an urgent need for the generation of new therapeutics, in particular, against new targets. The association of the corticotrophin releasing factor (CRF) and the HPA axis indicates that CRF antagonists should be… CONTINUE READING
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    References

    SHOWING 1-10 OF 112 REFERENCES
    The role of corticotropin-releasing factor in depression and anxiety disorders.
    • 1,262
    • PDF
    The rationale for corticotropin-releasing hormone receptor (CRH-R) antagonists to treat depression and anxiety.
    • F. Holsboer
    • Psychology, Medicine
    • Journal of psychiatric research
    • 1999
    • 600
    The role of Corticotropin Releasing Factor in Depressive Illness: a Critical Review
    • A. J. Mitchell
    • Medicine, Psychology
    • Neuroscience & Biobehavioral Reviews
    • 1998
    • 120
    Hypercortisolemia and depression.
    • 296
    The role of corticotropin-releasing factor in drug addiction.
    • 425
    • PDF
    Neurobiology of Depression
    • 1,407
    • PDF
    Nonpeptide Corticotropin-Releasing Hormone Receptor Type 1 Antagonists and Their Applications in Psychosomatic Disorders
    • 19
    Physiological and Neurochemical Aspects of Corticotropin-Releasing Factor Actions in the Brain: The Role of the Locus Coeruleus
    • 52
    Elevated concentrations of CSF corticotropin-releasing factor-like immunoreactivity in depressed patients.
    • 1,427
    The Corticotropin-Releasing Factor1 Receptor Antagonist R121919 Attenuates the Behavioral and Endocrine Responses to Stress
    • 90
    • PDF