The Role of the Exocyst in MMP Secretion and Actin Dynamics during Tumor Cell Invadopodia Formation

@inproceedings{Liu2009TheRO,
  title={The Role of the Exocyst in MMP Secretion and Actin Dynamics during Tumor Cell Invadopodia Formation},
  author={Jianglan Liu and Peng Yue and Vira V. Artym and Susette C. Mueller and Wei Guo},
  year={2009}
}
Invadopodia are actin-rich membrane protrusions formed by tumor cells that degrade the extracellular matrix for invasion. Invadopodia formation involves membrane protrusions driven by Arp2/3-mediated actin polymerization and secretion of matrix metalloproteinases (MMPs) at the focal degrading sites. The exocyst mediates the tethering of post-Golgi secretory vesicles at the plasma membrane for exocytosis, and has recently been implicated in regulating actin dynamics during cell migration. Here… CONTINUE READING

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