The Role of microsomal triglyceride transfer protein and dietary cholesterol in chylomicron production in diabetes

@article{Gleeson1999TheRO,
  title={The Role of microsomal triglyceride transfer protein and dietary cholesterol in chylomicron production in diabetes},
  author={Aine Gleeson and Kay Anderton and Daphne Owens and Andrew Bennett and Patrick Collins and Alan D Johnson and David White and Gerald H. Tomkin},
  journal={Diabetologia},
  year={1999},
  volume={42},
  pages={944-948}
}
Aims/hypothesis. The aim of this study was to examine factors involved in chylomicron production in the streptozotocin diabetic rat, our hypothesis being that the synthesis of the chylomicron is abnormal in diabetes. Methods. Diabetic rats (n = 20) were paired with control rats (n = 20). Cholesterol emulsion was given by gavage and the lymph duct was cannulated. Lymph was collected for 4 h. Chylomicrons were prepared from the lymph by ultracentrifugation. Lymph apolipoprotein B48 was isolated… CONTINUE READING