The Role of b 7 Integrins in CD 8 T Cell Trafficking During an Antiviral Immune Response

Abstract

The requirement of b 7 integrins for lymphocyte migration was examined during an ongoing immune response in vivo. Transgenic mice (OT-I) expressing an ovalbumin-specific major histocompatibility complex class I–restricted T cell receptor for antigen were rendered deficient in expression of all b 7 integrins or only the a E b 7 integrin. To quantitate the relative use of b 7 integrins in migration in vivo, equal numbers of OT-I and OT-Ib 7 2 / 2 or OT-Ia E 2 / 2

Cite this paper

@inproceedings{Parker1999TheRO, title={The Role of b 7 Integrins in CD 8 T Cell Trafficking During an Antiviral Immune Response}, author={Christina M. Parker and Sara H. Olson}, year={1999} }