The Role of a Conserved Lysine in Chloride- and Voltage-dependent ClC-0 Fast Gating

@article{Engh2007TheRO,
  title={The Role of a Conserved Lysine in Chloride- and Voltage-dependent ClC-0 Fast Gating},
  author={Anita M. Engh and Jos{\'e} D. Faraldo-G{\'o}mez and Merritt Maduke},
  journal={The Journal of General Physiology},
  year={2007},
  volume={130},
  pages={351 - 363}
}
ClC-0 is a chloride channel whose gating is sensitive to voltage, chloride, and pH. In a previous publication, we showed that the K149C mutation causes a +70-mV shift in the voltage dependence of ClC-0 fast gating. In this paper we analyze the effects of a series of mutations at K149 on the voltage and chloride dependence of gating. By fitting our data to the previously proposed four-state model for ClC-0 fast gating, we show which steps in fast-gate opening are likely to be affected by these… CONTINUE READING

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