The Role of Xgrip210 in γ-Tubulin Ring Complex Assembly and Centrosome Recruitment

@article{Zhang2000TheRO,
  title={The Role of Xgrip210 in γ-Tubulin Ring Complex Assembly and Centrosome Recruitment},
  author={L. Zhang and T. J. Keating and A. Wilde and G. Borisy and Y. Zheng},
  journal={The Journal of Cell Biology},
  year={2000},
  volume={151},
  pages={1525 - 1536}
}
  • L. Zhang, T. J. Keating, +2 authors Y. Zheng
  • Published 2000
  • Biology, Medicine
  • The Journal of Cell Biology
  • The γ-tubulin ring complex (γTuRC), purified from the cytoplasm of vertebrate and invertebrate cells, is a microtubule nucleator in vitro. Structural studies have shown that γTuRC is a structure shaped like a lock-washer and topped with a cap. Microtubules are thought to nucleate from the uncapped side of the γTuRC. Consequently, the cap structure of the γTuRC is distal to the base of the microtubules, giving the end of the microtubule the shape of a pointed cap. Here, we report the cloning and… CONTINUE READING

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