The Role of Vinculin in the Regulation of the Mechanical Properties of Cells

@article{Mierke2009TheRO,
  title={The Role of Vinculin in the Regulation of the Mechanical Properties of Cells},
  author={Claudia Tanja Mierke},
  journal={Cell Biochemistry and Biophysics},
  year={2009},
  volume={53},
  pages={115-126}
}
Vinculin couples as a focal adhesion protein the extracellular matrix (ECM) through integrins to the actomyosin cytoskeleton. During the last years vinculin has become the focus of cell mechanical measurements and a key protein regulating the transmission of contractile forces. In earlier reports vinculin has been described as an inhibitor of cell migration on planar substrates, because knock-out of vinculin in F9 mouse embryonic carcinoma cells and mouse embryonic fibroblasts showed increased… CONTINUE READING
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