The Role of Therapeutic Leukapheresis in Hyperleukocytotic AML

@inproceedings{Pastore2014TheRO,
  title={The Role of Therapeutic Leukapheresis in Hyperleukocytotic AML},
  author={Friederike Pastore and Alessandro Pastore and Georg Wittmann and Wolfgang Hiddemann and Karsten Spiekermann},
  booktitle={PloS one},
  year={2014}
}
PURPOSE Hyperleukocytosis in AML with leukostasis is a serious life-threatening condition leading to a high early mortality which requires immediate cytoreductive therapy. Therapeutic leukapheresis is currently recommended by the American Society of Apheresis in patients with a WBC>100 G/l with signs of leukostasis, but the role of prophylactic leukapheresis before clinical signs of leukostasis occur is unclear. PATIENTS We retrospectively analyzed the role of leukapheresis in 52 patients… CONTINUE READING

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