The Role of Telomeres in Stem Cells and Cancer

@article{Gnes2013TheRO,
  title={The Role of Telomeres in Stem Cells and Cancer},
  author={Cagatay G{\"u}nes and Karl Lenhard Rudolph},
  journal={Cell},
  year={2013},
  volume={152},
  pages={390-393}
}
Telomere shortening impairs proliferation of transformed cells but also leads to cancer initiation by inducing chromosomal instability. Here, we discuss recent developments in our understanding of the role of telomeres in replication stress and how telomerase expression in somatic stem cells may affect genome integrity control and carcinogenesis. 
Recent Discussions
This paper has been referenced on Twitter 13 times over the past 90 days. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.
83 Citations
3 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 83 extracted citations

References

Publications referenced by this paper.
Showing 1-3 of 3 references

Proc

  • R. B. Cervantes, J. R. Stringer, C. Shao, J. A. Tischfield, P. J. Stambrook
  • Natl. Acad. Sci. USA 99, 3586–3590.
  • 2002
Highly Influential
3 Excerpts

Nat

  • Y. Zhang, M. Jasin
  • Struct. Mol. Biol. 18, 80–84.
  • 2011

Embo J

  • R. Rai, H. Zheng, +4 authors S. Chang
  • 29, 2598–2610.
  • 2010
1 Excerpt

Similar Papers

Loading similar papers…