The Role of Spirochetes in Periodontal Disease

  title={The Role of Spirochetes in Periodontal Disease},
  author={Walter J. Loesche},
  journal={Advances in Dental Research},
  pages={275 - 283}
  • W. Loesche
  • Published 1 November 1988
  • Medicine, Biology
  • Advances in Dental Research
The spirochetal accumulation in subgingival plaque appears to be a function of the clinical severity of periodontal disease. It is not known how many different spirochetal species colonize the plaque, but based upon size alone, there are small, intermediate-sized, and large spirochetes. Four species of small spirochetes are cultivable, and of these, T. denticola has been shown to possess proteolytic and keratinolytic enzymes as well as factors or mechanisms which suppress lymphocyte… 

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