The Role of Small Heterodimer Partner (SHP) in NAFLD Improvement after Vertical Sleeve Gastrectomy in Mice

@inproceedings{Myronovych2014TheRO,
  title={The Role of Small Heterodimer Partner (SHP) in NAFLD Improvement after Vertical Sleeve Gastrectomy in Mice},
  author={Andriy Myronovych and Rosa-Maria Salazar-Gonzales and Karen Koeninger Ryan and Lisa. Miles and Wujuan Zhang and Pinky Jha and Li Wang and Kenneth David Reginald Setchell and Randy J Seeley and Rohit Kohli},
  year={2014}
}
Objective—Bile acids (BA) are elevated after vertical sleeve gastrectomy (VSG) and farnesoidX-receptor (FXR) is critical to the success of murine VSG. BA down-regulate hepatic lipogenesis by activating the FXR-small heterodimer partner (SHP) pathway. We tested the role of SHP in fatty liver disease (NAFLD) improvement after VSG. Design and Methods—Wild type (WT), SHP liver-transgenic (SHP-Tg) and SHP knockout (SHP-KO) high-fat diet (HFD) fed mice underwent either VSG or Sham surgery. Body… CONTINUE READING

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