The Role of Serotonin in Antipsychotic Drug Action

@article{Meltzer1999TheRO,
  title={The Role of Serotonin in Antipsychotic Drug Action},
  author={Herbert Y. Meltzer},
  journal={Neuropsychopharmacology},
  year={1999},
  volume={21},
  pages={106S-115S}
}
  • H. Meltzer
  • Published 1 August 1999
  • Psychology, Medicine
  • Neuropsychopharmacology
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The role of serotonin in the NMDA receptor antagonist models of psychosis and cognitive impairment
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The present findings support the hypothesis that antagonism at 5-HT2A receptors contributes to the in vivo actions of atypical antipsychotics such as olanzapine and clozapine, and indicate that PCP increases locomotor activity, at least in part, due to actions at5- HT2A, but not 5- HT3 or5-HT1A, receptors.
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Atypical antipsychotic drugs as a group appear to be superior to typical neuroleptics with regard to cognitive function, however, available data suggest that these drugs produce significant differences in specific cognitive functions.
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