The Role of S100B in the Interaction Between Adipocytes and Macrophages

  title={The Role of S100B in the Interaction Between Adipocytes and Macrophages},
  author={Atsushi Fujiya and Hiroshi Nagasaki and Yusuke Seino and Tetsuji Okawa and Jiro Kato and Ayako Fukami and Tatsuhito Himeno and Eita Uenishi and Shin Tsunekawa and Hideki Kamiya and Jiro Nakamura and Yutaka Oiso and Yoji Hamada},
  volume={22 2},
OBJECTIVE The S100 calcium binding protein B (S100B) implicated in brain inflammation acts via the receptor of advanced glycation end products (RAGE) and is also secreted from adipocytes. We investigated the role of S100B in the interaction between adipocytes and macrophages using a cell-culture model. DESIGN AND METHODS RAW264.7 macrophages (RAW) were stimulated by recombinant S100B to observe alterations in TNF-α and M1 markers; 3T3-L1 adipocytes (L1) were stimulated by TNF-α to examine… CONTINUE READING
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