The Role of Reactive Oxygen Species (ROS) in the Formation of Extracellular Traps (ETs) in Humans

@inproceedings{Stoiber2015TheRO,
  title={The Role of Reactive Oxygen Species (ROS) in the Formation of Extracellular Traps (ETs) in Humans},
  author={Walter Stoiber and Astrid Obermayer and Peter Steinbacher and Wolf-Dietrich Krautgartner and Michael Breitenbach and Peter Eckl},
  booktitle={Biomolecules},
  year={2015}
}
Extracellular traps (ETs) are reticulate structures of extracellular DNA associated with antimicrobial molecules. Their formation by phagocytes (mainly by neutrophils: NETs) has been identified as an essential element of vertebrate innate immune defense. However, as ETs are also toxic to host cells and potent triggers of autoimmunity, their role between pathogen defense and human pathogenesis is ambiguous, and they contribute to a variety of acute and chronic inflammatory diseases. Since the… CONTINUE READING
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