The Role of Purinergic Receptors in Cancer-Induced Bone Pain

@inproceedings{Falk2012TheRO,
  title={The Role of Purinergic Receptors in Cancer-Induced Bone Pain},
  author={Sarah Falk and Maria S Uldall and A Heegaard},
  booktitle={Journal of osteoporosis},
  year={2012}
}
Cancer-induced bone pain severely compromises the quality of life of many patients suffering from bone metastasis, as current therapies leave some patients with inadequate pain relief. The recent development of specific animal models has increased the understanding of the molecular and cellular mechanisms underlying cancer-induced bone pain including the involvement of ATP and the purinergic receptors in the progression of the pain state. In nociception, ATP acts as an extracellular messenger… CONTINUE READING