The Role of Prefrontal Cortex in Sensory Memory and Motor Preparation: An Event-Related fMRI Study

  title={The Role of Prefrontal Cortex in Sensory Memory and Motor Preparation: An Event-Related fMRI Study},
  author={Mark D’Esposito and Dana Ballard and Eric Zarahn and G. K. Aguirre},
Delayed-response tasks are behavioral paradigms in which subjects must remember stimulus attributes across a delay to subsequently perform the appropriate motor response. Quintana and Fuster (1992), reported that there exist subpopulations of neurons in monkey lateral prefrontal cortex (PFC) whose firing rates during the delay are tuned to either sensorial attributes of the stimulus (i.e., involved in sensory memory) or the direction of a postdelay motor response associated with the stimulus (i… 

Figures from this paper

Delay-period Activity in the Prefrontal Cortex: One Function Is Sensory Gating

  • B. Postle
  • Psychology, Biology
    Journal of Cognitive Neuroscience
  • 2005
Results are consistent with the view that processes related to sensory gating account for a portion of the delay-period activity that is routinely observed in the dlPFC.

Spatial attention and memory versus motor preparation: premotor cortex involvement as revealed by fMRI.

fMRI results indicate that the brain networks underlying the two functional domains overlap in the caudate nucleus and presupplementary motor area, and possibly in lateral prefrontal cortex as well, but involve different dorsal premotor fields.

Multiple Movement Representations in the Human Brain: An Event-Related fMRI Study

The functional anatomy of movement representations in the context of an associative visuomotor task with instructed delays is investigated and suggests that goal-directed preparatory activity relies on both visuo-motor and visuoperceptual areas.

Delay-related cerebral activity and motor preparation

Prefrontal cortical contributions to working memory: evidence from event-related fMRI studies

Data from a series of event-related functional magnetic-resonance-imaging studies of delayed-response tasks that were designed to investigate the role of different regions of the prefrontal cortex during different working-memory component processes conclude that lateral PFC is anatomically organized according to the types of cognitive operations one performs when attempting to temporarily maintain and manipulate information.

Rule‐dependent shifting of sensorimotor representation in the primate prefrontal cortex

It is found that a subset of mnemonic neurons in the lateral prefrontal cortex changed their representation from cue to saccade direction, and the discriminability for saccades direction of these neurons tended to appear soon after the behavioural rule presentation, indicating their significant dependency on a behavioural rule.

Role of prefrontal cortex and the midbrain dopamine system in working memory updating

High-resolution fMRI measurements in brainstem dopaminergic nuclei found phasic responses after presentation of context stimuli relative to other stimuli, consistent with the timing of a gating signal that regulates the encoding of representations in PFC.

Frontal Networks for Learning and Executing Arbitrary Stimulus-Response Associations

Functional magnetic resonance imaging was performed while subjects learned by trial and error to associate sets of abstract visual stimuli with arbitrary manual responses and showed that distinct components of the dorsolateral, ventrolateral, and anterior PFC, lateral premotor cortex, supplementary motor area, and the striatum are involved in learning versus executing categorical S-R rules.

Comparison of memory- and visually guided saccades using event-related fMRI.

It is concluded that activation differences revealed by previous blocked experiments have different sources in different areas and that cortical saccade regions exhibit delay-related activation differences.



Mnemonic and predictive functions of cortical neurons in a memory task

These findings suggest that neurons from prefrontal and parietal cortex are part of distributed networks, with representational and operational properties, for visuo- motor cognitive processing.

Transient and sustained activity in a distributed neural system for human working memory

Using fMRI to obtain dynamic measures of neural activity related to different components of a face working memory task, a continuum of functional specialization is revealed, from occipital through multiple prefrontal areas, regarding each area's relative contribution to perceptual and mnemonic processing.

Visuospatial coding in primate prefrontal neurons revealed by oculomotor paradigms.

1. Visual responses and their relationship to delay-period activity were studied by recording single neuron activity from the prefrontal cortex of rhesus monkeys while they performed an oculomotor

Spatial and temporal factors in the role of prefrontal and parietal cortex in visuomotor integration.

The results indicate that posterior parietal areas participate in spatial processing and in active memory of spatial information, whereas prefrontal areas subserve a broader role of visuomotor processing and cross-temporal integration of both spatial and nonspatial information.

Visuospatial versus visuomotor activity in the premotor and prefrontal cortex of a primate

  • G. di PellegrinoS. Wise
  • Psychology, Biology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1993
The hypothesis that the motor significance of visuospatial cues should commonly affect neuronal activity in the premotor cortex, but less commonly do so in the prefrontal cortex is tested and confirmed.

Temporal dynamics of brain activation during a working memory task

Functional magnetic resonance imaging is used to examine brain activation in human subjects during performance of a working memory task and to show that prefrontal cortex along with parietal cortex appears to play a role in active maintenance.