The Role of Phosphatases in the Initiation of Skeletal Mineralization

@article{Milln2012TheRO,
  title={The Role of Phosphatases in the Initiation of Skeletal Mineralization},
  author={J. L. Mill{\'a}n},
  journal={Calcified Tissue International},
  year={2012},
  volume={93},
  pages={299-306}
}
Endochondral ossification is a carefully orchestrated process mediated by promoters and inhibitors of mineralization. Phosphatases are implicated, but their identities and functions remain unclear. Mutations in the tissue-nonspecific alkaline phosphatase (TNAP) gene cause hypophosphatasia, a heritable form of rickets and osteomalacia, caused by an arrest in the propagation of hydroxyapatite (HA) crystals onto the collagenous extracellular matrix due to accumulation of extracellular inorganic… CONTINUE READING