The Role of Pharmacogenetics in the Metabolism of Antiepileptic Drugs

@article{Klotz2007TheRO,
  title={The Role of Pharmacogenetics in the Metabolism of Antiepileptic Drugs},
  author={Ulrich Klotz},
  journal={Clinical Pharmacokinetics},
  year={2007},
  volume={46},
  pages={271-279}
}
  • U. Klotz
  • Published 2007
  • Biology, Medicine
  • Clinical Pharmacokinetics
Several different factors, including pharmacogenetics, contribute to inter-individual variability in drug response. Like most other agents, many antiepileptic drugs (AEDs) are metabolised by a variety of enzymatic reactions, and the cytochrome P450 (CYP) superfamily has attracted considerable attention. Some of those CYPs exist in the form of genetic (allelic) variants, which may also affect the plasma concentrations or drug exposure (area under the plasma concentration-time curve [AUC]) of… 

[Pharmacogenetics and antiepileptic drug metabolism: implication of genetic variants in cytochromes P450].

The identification of interindividual variability in the response to AEDs may allow the personalized treatment with the aim of maximize the efficiency and minimize risk, regardless of the clinical variability and adverse effects could be manifest in a minority of the patients.

Update on the Genetic Polymorphisms of Drug-Metabolizing Enzymes in Antiepileptic Drug Therapy

The state of research on the effects of mutations of drug-metabolizing enzymes on the pharmacokinetics and pharmacodynamics of AED therapies is summarized and future directions for the dose-adjustment of A ED are discussed.

Implications of pharmacogenetics for the therapeutic use of antiepileptic drugs

This review summarizes the pharmacogenetics (PGx) of AEDs and provides a model-based approach that enables the integration of PGx data with other relevant sources of variability, such as demographic characteristics and co-medications.

The clinical impact of cytochrome P450 polymorphisms on anti-epileptic drug therapy

It is reported that the CYP2C19-deficient genotype is associated with the serum concentration of an active metabolite of clobazam, N-desmethylclobazem, and with the clinical efficacy of clOBazam therapy.

Farmacogenética e antiepilépticos (farmacologia das drogas antiepilépticas: da teoria à prática)

The optimized use of antiepileptic drugs to treatment of epilepsy is usually compromised by lack of therapeutic response, unexpected side effects and unexplained variations of antIEpileptics plasma levels, which could explain some of these problems.

The clinical impact of pharmacogenetics on the treatment of epilepsy

This article reviews the published work with particular emphasis on pharmacogenetic alterations that may affect efficacy, tolerability, and safety of antiepileptic drugs (AEDs), including variation in genes encoding drug target, drug transport, drug metabolizing, and human leucocyte antigen (HLA) proteins.

The effect of polymorphic metabolism enzymes on serum phenytoin level

The mean serum concentration of phenytoin of the polymorphic patients with epilepsy was higher than that for the wild-type alleles both in the monotherapy and polytherapy patients.

CYP3A5∗3 and C3435T MDR1 Polymorphisms in Prognostication of Drug-Resistant Epilepsy in Children and Adolescents

The study failed to corroborate association between polymorphism CYP3A5∗3 and C3435T polymorphism in MDR1 gene and pharmacoresistant epilepsy and do not confirm the prognostic value of the polymorphisms examined in the prognostication of drug resistance in epilepsies.

Pharmacogenetics of oral anticoagulant therapy.

The observational studies from the last decade provided valuable insights into the effects of genetic factors on variability in coumarin response and randomized clinical trials are needed to evaluate whether this genetic information will improve the benefit-risk ratio of coumarins.
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