The Role of Particle Therapy in the Risk of Radio-induced Second Tumors: A Review of the Literature

@article{Facoetti2019TheRO,
  title={The Role of Particle Therapy in the Risk of Radio-induced Second Tumors: A Review of the Literature},
  author={Angelica Facoetti and Amelia Barcellini and Francesca Valvo and M. Pullia},
  journal={AntiCancer Research},
  year={2019},
  volume={39},
  pages={4613 - 4617}
}
One of the most important late side-effects of radiation therapy is the development of radiation-induced secondary malignancies. In the last years, this topic has significantly influenced treatment decision-making as the number of long-term cancer survivors has significantly increased with advances in treatment modalities. All efforts are being made to prevent the incidence of tumors induced by radiation. In this review article we summarize the current knowledge about treatment-related… 
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An 80-year-old woman with a squamous cell carcinoma of the vagina after a history of pelvic radiation and vaginal brachytherapy delivered for a previous endometrial adenocarcinoma received proton beam radiotherapy with a complete response after 12 months and mild toxicity.
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CIRT as re-irradiation for locally recurrent rectal cancer emerges as a safe and valid treatment with an acceptable rate of morbidity of surrounding healthy tissue.
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A case of angiosarcoma of the scalp treated successfully with proton beam radiotherapy is reported, a rare malignancy concerning around 2% of soft-tissue sarcomas and 5% of cutaneous soft- TSPs.
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TLDR
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TLDR
CIRT for axial BSTS resulted in mild toxicity, showing promising results in terms of clinical outcomes, and Cox proportional-hazards model confirmed that GTV >1,000 ml was related to worse local control.
Angiosarcomaafteradjuvantradiotherapy in high-risksquamouscell carcinoma of the vulva: a case report
TLDR
A 75-year-old woman who underwent deep total vulvectomy with inguinal-femoral lymphadenectomy for high-risk, keratinizing variant HPV-negative, squamous cell carcinoma of the vulva is described, showing that the use of new technologies allows the delivery of high doses of radiotherapy, significantly correlated with a better prognosis, but also associated with fortunately rare morbidity, such as radiation-induced angiosarcoma.
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