The Role of Particle Therapy in the Risk of Radio-induced Second Tumors: A Review of the Literature

@article{Facoetti2019TheRO,
  title={The Role of Particle Therapy in the Risk of Radio-induced Second Tumors: A Review of the Literature},
  author={Angelica Facoetti and Amelia Barcellini and Francesca Valvo and M. Pullia},
  journal={AntiCancer Research},
  year={2019},
  volume={39},
  pages={4613 - 4617}
}
One of the most important late side-effects of radiation therapy is the development of radiation-induced secondary malignancies. In the last years, this topic has significantly influenced treatment decision-making as the number of long-term cancer survivors has significantly increased with advances in treatment modalities. All efforts are being made to prevent the incidence of tumors induced by radiation. In this review article we summarize the current knowledge about treatment-related… 
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20 Citations

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A 75-year-old woman who underwent deep total vulvectomy with inguinal-femoral lymphadenectomy for high-risk, keratinizing variant HPV-negative, squamous cell carcinoma of the vulva is described, showing that the use of new technologies allows the delivery of high doses of radiotherapy, significantly correlated with a better prognosis, but also associated with fortunately rare morbidity, such as radiation-induced angiosarcoma.
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An update on the novel and promising druggable targets emerging from DDR pathways that can be exploited for radiosensitization is provided and challenges for ionizing radiation-induced signal transduction and targeted therapy are discussed.
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Image-based data mining applies to data collected from children
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...
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