The Role of Particle Therapy in the Risk of Radio-induced Second Tumors: A Review of the Literature

  title={The Role of Particle Therapy in the Risk of Radio-induced Second Tumors: A Review of the Literature},
  author={Angelica Facoetti and Amelia Barcellini and Francesca Valvo and M. Pullia},
  journal={AntiCancer Research},
  pages={4613 - 4617}
One of the most important late side-effects of radiation therapy is the development of radiation-induced secondary malignancies. In the last years, this topic has significantly influenced treatment decision-making as the number of long-term cancer survivors has significantly increased with advances in treatment modalities. All efforts are being made to prevent the incidence of tumors induced by radiation. In this review article we summarize the current knowledge about treatment-related… 
Hadrontherapy techniques for breast cancer.
Therapeutic challenges in radiation-induced salivary gland cancers.
Reirradiation with protons and carbon ions demonstrated to be feasible, safe and to offer good local control rates, with the possibility of overcoming radioresistance and dosimetric issues in previously irradiated cancer patients.
Is a tailored strategy using proton beam radiotherapy for reirradiation advantageous for elderly women? A case report
An 80-year-old woman with a squamous cell carcinoma of the vagina after a history of pelvic radiation and vaginal brachytherapy delivered for a previous endometrial adenocarcinoma received proton beam radiotherapy with a complete response after 12 months and mild toxicity.
Re-irradiation With Carbon Ion Radiotherapy
This study aimed at evaluating the safety and efficacy of re-irradiation with Carbon Ion Radiotherapy (CIRT) in rectal cancer patients with local recurrentrectal cancer.
Re-irradiation With Carbon Ion Radiotherapy for Pelvic Rectal Cancer Recurrences in Patients Previously Irradiated to the Pelvis
CIRT as re-irradiation for locally recurrent rectal cancer emerges as a safe and valid treatment with an acceptable rate of morbidity of surrounding healthy tissue.
Hadrontherapy for Thymic Epithelial Tumors: Implementation in Clinical Practice
This critical review aims to analyze the current status of hadrontherapy for TET irradiation to implement it at a larger scale and mainly relies on small-size proton therapy studies.
Is Proton Beam Radiotherapy Worthwhile in the Management of Angiosarcoma of the Scalp?
A case of angiosarcoma of the scalp treated successfully with proton beam radiotherapy is reported, a rare malignancy concerning around 2% of soft-tissue sarcomas and 5% of cutaneous soft- TSPs.
Current Situation of Proton Therapy for Hodgkin Lymphoma: From Expectations to Evidence
A critical review aims to examine the current practice of proton therapy for mediastinal HL irradiation and state-of-the-art RT techniques efficiently spare critical organs-at-risks without altering local control or overall survival.
Outcome and Toxicity of Carbon Ion Radiotherapy for Axial Bone and Soft Tissue Sarcomas
CIRT for axial BSTS resulted in mild toxicity, showing promising results in terms of clinical outcomes, and Cox proportional-hazards model confirmed that GTV >1,000 ml was related to worse local control.
Angiosarcomaafteradjuvantradiotherapy in high-risksquamouscell carcinoma of the vulva: a case report
A 75-year-old woman who underwent deep total vulvectomy with inguinal-femoral lymphadenectomy for high-risk, keratinizing variant HPV-negative, squamous cell carcinoma of the vulva is described, showing that the use of new technologies allows the delivery of high doses of radiotherapy, significantly correlated with a better prognosis, but also associated with fortunately rare morbidity, such as radiation-induced angiosarcoma.


Assessing the risk of second malignancies after modern radiotherapy
Risks from treatments such as particle therapy have not yet been determined and are unlikely to become apparent for many years, therefore, there is a need to develop risk assessments based on current knowledge of radiation-induced carcinogenesis.
Second Malignant Neoplasms Following Radiotherapy
  • Sanath Kumar
  • Medicine
    International journal of environmental research and public health
  • 2012
The incidence, etiology, and risk factors for SMN in various organs after radiotherapy are focused on.
Radiation-Induced Malignancies Making Radiotherapy a “Two-Edged Sword”: A Review of Literature
The aim of this review of literature was to discuss epidemiology, factors affecting and different settings in which RIM occur.
Radiation-induced second cancers: the impact of 3D-CRT and IMRT.
  • E. Hall, C. Wuu
  • Medicine, Physics
    International journal of radiation oncology, biology, physics
  • 2003
The calculated risk of fatal secondary malignancies from intensity-modulated radiation therapy.
Radiotherapy-Induced Malignancies: Review of Clinical Features, Pathobiology, and Evolving Approaches for Mitigating Risk
The goal of this review is to discuss epidemiologic, modeling, and radiotherapy delivery data, where these lines of research intersect and their potential impact on patient care.
Intensity-modulated radiation therapy, protons, and the risk of second cancers.
  • E. Hall
  • Medicine, Physics
    International journal of radiation oncology, biology, physics
  • 2006
Carbon Ion Radiotherapy in the Management of the Tumors of the Peripheral Nervous System
CIRT yielded good local control with a low rate of acute and late toxicities, and the preliminary results (outcomes and toxicity) of CIRT in the treatment of MPNSTs were reported.
Special radiobiological features of second cancer risk after particle radiotherapy.
  • K. Trott
  • Medicine, Physics
    Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics
  • 2017