The Role of Particle Therapy in the Risk of Radio-induced Second Tumors: A Review of the Literature

  title={The Role of Particle Therapy in the Risk of Radio-induced Second Tumors: A Review of the Literature},
  author={Angelica Facoetti and Amelia Barcellini and Francesca Valvo and M. Pullia},
  journal={AntiCancer Research},
  pages={4613 - 4617}
One of the most important late side-effects of radiation therapy is the development of radiation-induced secondary malignancies. In the last years, this topic has significantly influenced treatment decision-making as the number of long-term cancer survivors has significantly increased with advances in treatment modalities. All efforts are being made to prevent the incidence of tumors induced by radiation. In this review article we summarize the current knowledge about treatment-related… 
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An 80-year-old woman with a squamous cell carcinoma of the vagina after a history of pelvic radiation and vaginal brachytherapy delivered for a previous endometrial adenocarcinoma received proton beam radiotherapy with a complete response after 12 months and mild toxicity.
Re-irradiation With Carbon Ion Radiotherapy for Pelvic Rectal Cancer Recurrences in Patients Previously Irradiated to the Pelvis
CIRT as re-irradiation for locally recurrent rectal cancer emerges as a safe and valid treatment with an acceptable rate of morbidity of surrounding healthy tissue.
Hadrontherapy for Thymic Epithelial Tumors: Implementation in Clinical Practice
This critical review aims to analyze the current status of hadrontherapy for TET irradiation to implement it at a larger scale and mainly relies on small-size proton therapy studies.
Outcome and Toxicity of Carbon Ion Radiotherapy for Axial Bone and Soft Tissue Sarcomas
CIRT for axial BSTS resulted in mild toxicity, showing promising results in terms of clinical outcomes, and Cox proportional-hazards model confirmed that GTV >1,000 ml was related to worse local control.
Angiosarcomaafteradjuvantradiotherapy in high-risksquamouscell carcinoma of the vulva: a case report
A 75-year-old woman who underwent deep total vulvectomy with inguinal-femoral lymphadenectomy for high-risk, keratinizing variant HPV-negative, squamous cell carcinoma of the vulva is described, showing that the use of new technologies allows the delivery of high doses of radiotherapy, significantly correlated with a better prognosis, but also associated with fortunately rare morbidity, such as radiation-induced angiosarcoma.
DNA damage response signaling pathways and targets for radiotherapy sensitization in cancer
An update on the novel and promising druggable targets emerging from DDR pathways that can be exploited for radiosensitization is provided and challenges for ionizing radiation-induced signal transduction and targeted therapy are discussed.
Endometrial Cancer: When Upfront Surgery Is Not an Option.
The present paper reviews literature data on treatment options for endometrial cancer patients unfit for surgery and concludes that surgery is still a viable option for these patients.
Dosimetric comparison between intensity-modulated radiotherapy and volumetric-modulated arc therapy in patients of left-sided breast cancer treated with modified radical mastectomy
VMAT plans was equivalent or superior to IMRT plans in dose distribution, and was associated with slightly advantage in sparing of the heart and coronary arteries, and suggested VMAT as a preferred option in left-sided breast cancer patients treated with modified radical mastectomy.
Image-based data mining applies to data collected from children
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  • Computer Science
    Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics
  • 2022


Second Malignant Neoplasms Following Radiotherapy
  • Sanath Kumar
  • Medicine
    International journal of environmental research and public health
  • 2012
The incidence, etiology, and risk factors for SMN in various organs after radiotherapy are focused on.
Radiation-Induced Malignancies Making Radiotherapy a “Two-Edged Sword”: A Review of Literature
The aim of this review of literature was to discuss epidemiology, factors affecting and different settings in which RIM occur.
Radiation-induced second cancers: the impact of 3D-CRT and IMRT.
  • E. Hall, C. Wuu
  • Medicine, Physics
    International journal of radiation oncology, biology, physics
  • 2003
Radiotherapy-Induced Malignancies: Review of Clinical Features, Pathobiology, and Evolving Approaches for Mitigating Risk
The goal of this review is to discuss epidemiologic, modeling, and radiotherapy delivery data, where these lines of research intersect and their potential impact on patient care.
Intensity-modulated radiation therapy, protons, and the risk of second cancers.
  • E. Hall
  • Medicine, Physics
    International journal of radiation oncology, biology, physics
  • 2006
Carbon Ion Radiotherapy in the Management of the Tumors of the Peripheral Nervous System
CIRT yielded good local control with a low rate of acute and late toxicities, and the preliminary results (outcomes and toxicity) of CIRT in the treatment of MPNSTs were reported.
Second malignancies in prostate carcinoma patients after radiotherapy compared with surgery
In the treatment of prostate carcinoma, radiotherapy and surgery are common choices of comparable efficacy; thus a realistic comparison of the potential long term sequelae, such as the risk of second