The Role of Pancreatic Preproglucagon in Glucose Homeostasis in Mice.

@article{Chambers2017TheRO,
  title={The Role of Pancreatic Preproglucagon in Glucose Homeostasis in Mice.},
  author={Adam P. Chambers and Joyce E. Sorrell and April Haller and Karen J. Roelofs and Chelsea R. Hutch and Ki-Suk Kim and Ruth Gutierrez-Aguilar and Bailing Li and Daniel J Drucker and David A D'Alessio and Randy J Seeley and Darleen A Sandoval},
  journal={Cell metabolism},
  year={2017},
  volume={25 4},
  pages={
          927-934.e3
        }
}
Glucagon-like peptide 1 (GLP-1) is necessary for normal gluco-regulation, and it has been widely presumed that this function reflects the actions of GLP-1 released from enteroendocrine L cells. To test the relative importance of intestinal versus pancreatic sources of GLP-1 for physiological regulation of glucose, we administered a GLP-1R antagonist, exendin-[9-39] (Ex9), to mice with tissue-specific reactivation of the preproglucagon gene (Gcg). Ex9 impaired glucose tolerance in wild-type mice… CONTINUE READING
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