The Role of PPARγ in Advanced Glycation End Products-Induced Inflammatory Response in Human Chondrocytes

@inproceedings{Ma2015TheRO,
  title={The Role of PPARγ in Advanced Glycation End Products-Induced Inflammatory Response in Human Chondrocytes},
  author={Chi Ma and Ying Zhang and Yu-qing Li and Cheng Chen and Wei Cai and Yue-lin Zeng and Bradley Taylor},
  booktitle={PloS one},
  year={2015}
}
OBJECTIVE Advances made in the past ten years highlight the notion that peroxisome proliferator-activated receptors gamma (PPARγ) has protective properties in the pathophysiology of osteoarthritis (OA). The aim of this study was to define the roles of PPARγ in AGEs-induced inflammatory response in human chondrocytes. METHODS Primary human chondrocytes were stimulated with AGEs in the presence or absence of neutralizing antibody against RAGE (anti-RAGE), MAPK specific inhibitors and PPAR… CONTINUE READING
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