The Role of PML in Tumor Suppression

  title={The Role of PML in Tumor Suppression},
  author={Paolo Salomoni and Pier Paolo Pandolfi},
The PML gene, involved in the t(15;17) chromosomal translocation of acute promyelocytic leukemia (APL), encodes a protein which localizes to the PML-nuclear body, a subnuclear macromolecular structure. PML controls apoptosis, cell proliferation, and senescence. Here, we review the current understanding of its role in tumor suppression. 


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Role of promyelocytic leukemia (PML) protein

  • P. P. Pandolfi
  • 2001
Highly Influential
9 Excerpts

Regulation of p 53 activity by that one of the contributing mechanisms by which PML its interaction with homeodomaininteracting protein

  • C. Shiels, P. S. Freemont
  • 2002

TGF - betainduced apoptosis is mediated by localize in PMLNB , such as proteasome subunits ( Lalthe adapter protein Daxx that facilitates JNK activation

  • F. De Bels, M. Koken, J. Feunteun, J. C. Ameisen, H. de The
  • Nat . Cell Biol .
  • 2001

The theory of APL

  • R. Carbone, C. Sebastiani, M. Cioce
  • Oncogene
  • 2001

sumolation in nuclear body formation , 11 S proteasome recruitment , and As 2 O 3induced PML or PML / retinoic acid receptor In Search of Additional Biochemical Functions  degradation

  • S. Vallian, Z. M. Mu, M. C. Hung, K. S. Chang
  • J . Exp . Med .
  • 2001

PML is induced by oncogenic ras and bodies

  • P. Turelli, V. Doucas, +10 authors D. Trono
  • Genes Dev . Genes Dev .
  • 2000

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