The Role of PML in Tumor Suppression

@article{Salomoni2002TheRO,
  title={The Role of PML in Tumor Suppression},
  author={Paolo Salomoni and Pier Paolo Pandolfi},
  journal={Cell},
  year={2002},
  volume={108},
  pages={165-170}
}
The PML gene, involved in the t(15;17) chromosomal translocation of acute promyelocytic leukemia (APL), encodes a protein which localizes to the PML-nuclear body, a subnuclear macromolecular structure. PML controls apoptosis, cell proliferation, and senescence. Here, we review the current understanding of its role in tumor suppression. 

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