The Role of PIWI and the miRNA Machinery in Drosophila Germline Determination

@article{Megosh2006TheRO,
  title={The Role of PIWI and the miRNA Machinery in Drosophila Germline Determination},
  author={Heather B. Megosh and Daniel N Cox and Chris A. Campbell and Haifan Lin},
  journal={Current Biology},
  year={2006},
  volume={16},
  pages={1884-1894}
}
BACKGROUND The germ plasm has long been demonstrated to be necessary and sufficient for germline determination, with translational regulation playing a key role in the process. Beyond this, little is known about molecular activities underlying germline determination. RESULTS We report the function of Drosophila PIWI, DICER-1, and dFMRP (Fragile X Mental Retardation Protein) in germline determination. PIWI is a maternal component of the polar granule, a germ-plasm-specific organelle essential… CONTINUE READING

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