The Role of Oxytocin in Relation to Female Sexual Arousal

  title={The Role of Oxytocin in Relation to Female Sexual Arousal},
  author={W. Blaicher and D. Gruber and C. Bieglmayer and A. Blaicher and W. Knogler and J. Huber},
  journal={Gynecologic and Obstetric Investigation},
  pages={125 - 126}
Oxytocin is clearly involved in human reproduction and serves an important role in sexual arousal. Oxytocin serum levels were measured before and after sexual stimulation in 12 healthy women. Values of oxytocin 1 min after orgasm were significantly higher (p < 0.05) than baseline levels. This finding supports the hypothesis that oxytocin plays a major part in human sexual response both in neuroendocrine function and postcoital behavior. 
The role of oxytocin in mating and pregnancy
This review will discuss the most recent findings from fMRI data and the effects of exogenous peripheral OT administration, and consider hypotheses of the roles played by central and systemic OT release as well as their control and modulation in the female, summarizing recently findings from animal research. Expand
The acute effects of intranasal oxytocin administration on endocrine and sexual function in males
In conclusion, intranasally administered OT leads to a marked increase in OT plasma levels together with increased secretion of catecholamines when subjects are engaged in sexual activity in a laboratory setting. Expand
Effects of Intranasal Oxytocin Administration on Sexual Functions in Healthy Women: A Laboratory Paradigm
The findings indicate that OXT is not able to significantly increase subjective and objective parameters of sexual function in a setting with high internal validity; however, this might be different in a more naturalistic setting. Expand
Menstrual cycle-related changes in plasma oxytocin are relevant to normal sexual function in healthy women
It is suggested that plasma OT fluctuates throughout the menstrual cycle in normally cycling healthy fertile women with adequate sexual activity but not taking any oral contraceptive pill, apparently confirming its role in peripheral activation of sexual function. Expand
Orgasm-induced prolactin secretion: feedback control of sexual drive?
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The traditional concept of 'hormone' continues to apply to the role of testosterone and oestradiol in sexual arousal, peptides present a more complex role, partly because of the multiple roles and sites of action of most peptides. Expand
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The influence of endocrine, neurotransmitter, and central nervous system influences on male and female sexual function are discussed for sexual desire, arousal, and orgasm or ejaculation stages of sexual responding. Expand
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Right amygdala activation was lower in postpartum versus nulliparous women in response to sexual, infant, and neutral images, suggesting a generalized decrease in right amygdala responsiveness to arousing images with parturition. Expand
The role of oxytocin in male and female reproductive behavior.
An intriguing brain area is paid attention to, the ventrolateral part of the ventromedial hypothalamic nucleus (VMHvl), apparently functioning in both sexual and aggressive behavior, which are at first view completely opposite behavioral systems. Expand
Oxytocin increases VTA activation to infant and sexual stimuli in nulliparous and postpartum women
The findings show that postpartum decreases in sexual desire may in part be mediated by VTA activation, and oxytocin increased activation of the VTA but not NAc in response to sexual and infant stimuli. Expand


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More research is needed to clarify the role of oxytocin in human reproductive behaviors, including its potential 'aphrodisiac' or prosexual effect in women in the presence of the sex-steroid hormones. Expand
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The presence of biologically active nerve growth factor in the peripheral circulation of women during pregnancy, labour and lactation was investigated and an approximately five-fold increase in plasma NGF levels was found. Expand
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A positive correlation was observed between the midcycle elevation of estrogen (E) and the level of oxytocin- and estrogen-stimulated neurophysin (ESN) in the plasma of five of six women, the only described cyclic secretion of Oxytocin in humans. Expand
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Of particular importance at the level of the muscle cell are changes in the number of oxytocin receptors; a complex interaction between cAMP and phosphoinositide metabolism governs the intracellular level of calcium, thus regulating contractile activity. Expand
8 The endocrinology of parturition in the human
Summary Current evidence suggests that oestrogens, progesterone, relaxin, the prostaglandins, and oxytocin are all hormones concerned to a major degree with the onset and maintenance of parturition.Expand
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Sexual interest was found to be significantly higher in the follicular and ovulatory phases, than in the luteal, premenstrual, or menstrual phases, and sexual interest and feelings of well-being were correlated. Expand
Role of central oxytocin in the control of the milk ejection reflex
From numerous in vivo and in vitro observations, it appears that central oxytocin is released in the hypothalamic nuclei themselves, and the mechanism of the central release of the neuropeptide has still to be determined, especially in view of electrophysiological observations indicating that the release process within the hypothalamus is different from that within the neurohypophysis. Expand
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