The Role of Oxysterols in Human Cancer.

  title={The Role of Oxysterols in Human Cancer.},
  author={Alzbeta Kloudova and F Peter Guengerich and Pavel Soucek},
  journal={Trends in endocrinology and metabolism: TEM},
  volume={28 7},
Oxysterols are oxygenated derivatives of cholesterol formed in the human body or ingested in the diet. By modulating the activity of many proteins [e.g., liver X receptors (LXRs), oxysterol-binding proteins (OSBPs), some ATP-binding cassette (ABC) transporters], oxysterols can affect many cellular functions and influence various physiological processes (e.g., cholesterol metabolism, membrane fluidity regulation, intracellular signaling pathways). Therefore, the role of oxysterols is also… CONTINUE READING
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